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Levomenol

SKU: orb1685377

Description

Levomenol ((-)-α-Bisabolol) is a naturally occurring sesquiterpene alcohol with documented antioxidant, anti-inflammatory, and anti-apoptotic properties. It is widely used in research for studying skin inflammation, wound healing, and neuroprotection in both in vitro and in vivo models.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number23089-26-1
MW222.37
Purity96.01%
FormulaC15H26O
SMILES[C@](CCC=C(C)C)(C)(O)[C@]1(CCC(C)=CC1)[H]
TargetApoptosis,Others
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.99 mM);DMSO:22.5 mg/mL (101.18 mM)

Bioactivity

In Vivo
Levomenol inhibits the growth of L. amazonensis promastigotes and amastigotes (IC50s = 8.07 and 4.29 μg/ml, respectively). It also reduces the growth of L. infantum and L. donovani amastigotes (IC50s = 56.9 and 39.4 μM, respectively) with a cytotoxic concentration (CC50) value of greater than 1,000 μM in L929 cells.
In Vitro
Levomenol was able to activate a programmed cell death process in the promastigote stage of the parasite.It causes phosphatidylserine externalization and membrane damage.Moreover, it decreases the mitochondrial membrane potential and total ATP levels.These results highlight the potential use of Levomenol against both L. amazonensis and L. infantum, and further studies should be undertaken to establish it as novel leishmanicidal therapeutic agents.

Storage & Handling

StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

α-BISABOLOL, unsaturated sesquiterpene alcohol, inhibit, oral, neuroprotective effects, Inhibitor, Levomenol, a-BISABOLOL, alpha-BISABOLOL, (-)-α-BISABOLOL, antioxidant, anti-inflammatory, Apoptosis

Similar Products

  • Levomenol (Standard) [orb3140986]

    23089-26-1

    222.37

    C15H26O

    100 mg
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Key Properties

No computed properties available.

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Levomenol (orb1685377)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

10 mg
¥ 1,040.00
1 ml x 10 mM (in DMSO)
¥ 1,170.00
25 mg
¥ 1,300.00
50 mg
¥ 1,560.00
100 mg
¥ 1,950.00
200 mg
¥ 2,600.00
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