Levomepromazine

SKU: orb1707078

Description

Levomepromazine is an aliphatic phenothiazine with antipsychotic properties, functioning as a multi-receptor antagonist and a calcium release inducer. It is utilized in research models for neurodegenerative diseases, inflammation, and pain, based on its documented neuroprotective and antiviral activities in experimental studies.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	60-99-1
MW	328.47
Formula	C₁₉H₂₄N₂OS
SMILES	C([C@@H](CN(C)C)C)N1C=2C(SC=3C1=CC=CC3)=CC=C(OC)C2
Target	Others
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.04 mM);DMSO:30 mg/mL (91.33 mM)

Bioactivity

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In Vivo

Levomepromazine (5-20 mg/kg; Intraperitoneal injection) has analgesic, sedative and anti-injurious effects in mice .

In Vitro

Levomepromazine(0.01-200 μM,72h) increased the CYP3A4 activity of HU1832 to 152% at 2.5 μM. Levomepromazine (10 μM, 24 h) reduced Japanese encephalitis virus (JEV) -induced Neuro2a cell death, decreased JEV RNA levels and viral titers, and significantly inhibited JEV protein translation/replication complex formation and ROS production. Levomepromazine (10 μM, 24 h) reduces inflammation in microglia by inducing autophagy.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Methotrimeprazine, Levomepromazine

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Compound Identifiers

PubChem CID

72287 ↗

Key Properties

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No computed properties available.

Protocol Information

Find More Protocols

CAS Number:	1189805-51-3
MW:	334.51
Formula:	C₁₉H₂₄N₂OS

CAS Number:	851-68-3
MW:	328.47
Formula:	C₁₉H₂₄N₂OS

CAS Number:	7104-38-3
MW:	444.546
Formula:	C₂₃H₂₈N₂O₅S

CAS Number:	1236-99-3
MW:	364.932
Formula:	C₁₉H₂₅ClN₂OS

Levomepromazine

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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