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LFM-A13

SKU: orb1300970

Description

LFM-A13

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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LFM-A13

Key Properties

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CAS Number244240-24-2
MW360
Purity99.90% (May vary between batches)
FormulaC11H8Br2N2O2
SMILESN(C(/C(=C(/C)\O)/C#N)=O)C1=C(Br)C=CC(Br)=C1
TargetPLK|||JAK|||BTK
SolubilityH2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (6.94 mM);DMSO:67 mg/mL (186.11 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

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Target IC50
BTK:2.5 μM
In Vivo
In BALB/c mice bearing BCL-1 leukemia, combination of(Z)-LFM-A13 (50 mg/kg/day i.p.) and the standard triple-drug VPL prolongs the median survival time. In primary myeloma-bearing SCID-rab mice,(Z)-LFM-A13 inhibits osteoclast activity, prevents myeloma-induced bone resorption and suppresss myeloma growth.
In Vitro
In BTK+ B-lineage leukemic cells, (Z)-LFM-A13 enhances their sensitivity to ceramide- or vincristine-induced apoptosis. In BCL-1 cells, NALM-6 cells, or normal BALB/c splenocytes, LFM-13 inhibits the enzymatic activity of BTK in BCL-1 cells without affecting the BTK protein expression levels In human neutrophils, (Z)-LFM-A13 decreases the tyrosine phosphorylation induced by fMet-Leu-Phe and inhibits the production of superoxide anions and the stimulation of adhesion, chemotaxis, and phospholipase D activity.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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BTK, Btk, Bruton tyrosine kinase, PLK, JAK, Janus kinase, inhibit, Inhibitor, LFM A13, LFMA13, LFM-A13, LFM-A-13, Polo-like Kinase (PLK)

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
54676905 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

Select a size below

1 ml x 10 mM (in DMSO)
$ 70.00
5 mg
$ 70.00
10 mg
$ 90.00
25 mg
$ 140.00
50 mg
$ 210.00
100 mg
$ 330.00
200 mg
$ 460.00
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