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Lindleyin

SKU: orb1297583

Description

Lindleyin

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number59282-56-3
MW478.45
Purity99.74% (May vary between batches)
FormulaC23H26O11
SMILESCC(=O)CCc1ccc(O[C@@H]2O[C@H](COC(=O)c3cc(O)c(O)c(O)c3)[C@@H](O)[C@H](O)[C@H]2O)cc1
TargetEstrogen/progestogen Receptor|||Estrogen Receptor/ERR

Bioactivity

In Vitro
One herbal extract, Rhei rhizoma (rhubarb), acts as an agonist to both ERalpha and ERbeta. The phytochemical Lindleyin, a major component of rhubarb, might contribute to this estrogenic activity through ERalpha and ERbeta. 4-Hydroxytamoxifen, an ER antagonist, completely reversed the estrogenic activity of Lindleyin. Lindleyin binds to ERalpha in vitro, as demonstrated using a fluorescent polarization assay. The in vivo effect of rhubarb extract was studied using a vitellogenin assay system in the freshwater fish, Japanese medaka (Oryzias latipes). There were marked increases in serum vitellogenin levels in male medaka exposed to rhubarb extract

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ERR, Estrogen Receptor, EstrogenReceptor, Estrogen/progestogen Receptor, Estrogen Receptor/ERR, Inhibitor, Lindleyin, inhibit, progestogen Receptor, progestogenReceptor

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Key Properties

No computed properties available.

Protocol Information

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1 mg
$ 170.00
1 ml x 10 mM (in DMSO)
$ 370.00
5 mg
$ 370.00
10 mg
$ 520.00