Liothyronine sodium hydrate

SKU: orb1685775

Description

Liothyronine sodium hydrate (T3) is a synthetic thyroid hormone analog that acts as an agonist for both TRα and TRβ receptors. It is utilized in research areas such as hypothyroidism, neuroprotection in stroke models, and cognitive function studies, with demonstrated applications in investigating anticancer mechanisms in vitro and in vivo.

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	345957-19-9
Purity	98.19%
Formula	C₁₅H₁₁NNaO₄ xH₂O
SMILES	IC(C=C(C=C1I)C[C@H](N)C([O-])=O)=C1OC2=CC(I)=C(C=C2)O.[Na+].O xH2O
Target	Endogenous Metabolite,Thyroid hormone receptor(THR)

Bioactivity

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Target IC50	TRβ (human):2.33 nM\|TRα (human):2.33 nM
In Vitro	b>METHODS: Liothyronine sodium hydrate (100 μM, 3 weeks) was used to treat liver cancer cells (Mahlavu, SK-Hep-1, J5, 5328 and HepG2) and the cell growth was observed. RESULTS: Liothyronine sodium hydrate can stimulate the proliferation of liver cancer cells. Read more...

Storage & Handling

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Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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3,3',5-Triiodo-L-thyronine sodium hydrate, Thyroidhormonereceptor, Thyroidhormonereceptor(THR), Thyroid hormone receptor(THR), Thyroid hormone receptor, THR, T3 sodium hydrate, Triiodothyronine sodium hydrate, TRα, TRβ

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Compound Identifiers

PubChem CID

23687509 ↗

Key Properties

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No computed properties available.

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