Lirentelimab Antibody

SKU: orb1980575

Description

Lirentelimab (AK002) is a humanized monoclonal antibody targeting Siglec-8. It triggers apoptosis in activated eosinophils and inhibits mast cell activation, making it a research tool for studying conditions like systemic mastocytosis and allergic conjunctivitis. Its mechanisms have been investigated in both in vitro assays and in vivo preclinical models.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	2283348-97-8
MW	144.55 kDa
Purity	97.7% (SDS-PAGE); 99.7% (SEC-HPLC)
Target	Apoptosis

Bioactivity

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Target IC50	SIGLEC8:464 pM (affinity)
In Vivo	Lirentelimab significantly inhibited IgE-mediated mast cell activation after a single intravenous injection at a dose of 100 μg in a mouse model of systemic allergic reaction. Read more...
In Vitro	The antigen-binding fragment of Lirentelimab binds with an affinity of 464 pM to the extracellular structural domain of recombinant SIGLEC8. Lirentelimab exhibits a high affinity for in vitro-expressed SIGLEC8 as well as SIGLEC8 expressed on eosinophils and via the Fc region on NK cells. At a concentration of 1 µg/mL, Lirentelimab selectively binds to eosinophils in human peripheral blood as well as eosinophils and mast cells in human lung tissue. In addition, Lirentelimab induced apoptosis in IL-5-activated eosinophils when acted at concentrations ranging from 0.0001 to 100 μg/mL for 30 minutes. In peripheral blood leukocyte samples from healthy donors, Lirentelimab had a half-maximal effect concentration of 1.9 ng/mL on eosinophils and elicited an antibody-dependent cytotoxic response.Lirentelimab also reduced the number of eosinophils in isolated human tissues. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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AK 002, AK002, Anti-Siglec-8 Reference Antibody, Antolimab, Apoptosis

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Gene Symbol

Apoptosis

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