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Litorin acetate(55749-97-8 Free base)

SKU: orb1306597

Description

Litorin acetate is a bombesin receptor agonist derived from amphibian peptides. It is used in research to study smooth muscle contraction, gastrointestinal hormone secretion (e.g., gastrin), and nutrient metabolism suppression in vivo, with applications in physiology and pharmacology.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

MW1145.29
Purity97.64% (May vary between batches)
FormulaC53H72N14O13S
SMILESCC(O)=O.CSCC[C@@H](C(N)=O)NC([C@H](CC1=CC=CC=C1)NC([C@H](CC2=CNC=N2)NC(CNC([C@H](C(C)C)NC([C@H](C)NC([C@H](CC3=CNC4=C3C=CC=C4)NC([C@H](CCC(N)=O)NC([C@H](CC5)NC5=O)=O)=O)=O)=O)=O)=O)=O)=O
TargetBombesin Receptor
SolubilityDMSO:110.09 mg/mL (96.12 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

In Vivo
Litorin stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the nutriment in in vivo experiments.
In Vitro
99mTc-Litorin is developed for non-invasive imaging of tumors with overexpressed gastrin-releasing peptide receptors (GRP-R). [D-Phe1,Leu8,9]Litorin inhibits binding of 125I-[Tyr4] BN to murine Swiss 3T3 cells with a Ki of 5.1 nM. Litorin stimulates 3H-Thymidine incorporation in murine Swiss 3T3 cells with an EC50 of 2.3 nM.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Bombesin Receptor, BombesinReceptor, Litorin acetate, Litorin acetate(55749-97-8 Free base)
Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 mg
$ 120.00
5 mg
$ 270.00
10 mg
$ 400.00
25 mg
$ 630.00
50 mg
$ 900.00
100 mg
$ 1,220.00
DispatchUsually dispatched within 3-5 working days
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