LL-K8-22

SKU: orb1982623

Description

LL-K8-22 is a potent and selective dual degrader of CDK8-cyclin C, with DC50 values around 2.5 μM. It suppresses STAT1 S727 phosphorylation and inhibits oncogenic E2F/MYC transcriptional programs. This compound is a research tool for studying triple-negative breast cancer (TNBC) in both cellular and animal models.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

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Key Properties

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MW	573.77
Formula	C₃₇H₄₃N₅O
Target	STAT,Others,Early 2 Factor (E2F),PROTACs,CDK

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

STAT,Others,Early 2 Factor (E2F),PROTACs,CDK

Protocol Information

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CAS Number:	31685-38-8
MW:	194.31
Formula:	C₁₃H₂₂O

LL-K8-22

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Key Properties

Storage & Handling

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