Losmapimod hydrochloride

SKU: orb3172915

Description

Losmapimod hydrochloride (GW856553X) is an orally active, potent, and highly selective p38 alpha/beta MAPK inhibitor (IC50 = 0.8 nM). It greatly reduces the release of pro-inflammatory cytokines, including TNF-alpha and IL-6, by blocking inflammatory signaling cascades, showing remarkable efficacy in COPD and severe cardiovascular inflammation models.

Images & Validation

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Key Properties

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CAS Number	1246654-84-1
MW	419.92
Purity	99.98% (May vary between batches)
Formula	C₂₂H₂₇ClFN₃O₂
SMILES	Cl.O=C(NCC(C)(C)C)C1=CN=C(C=C1)C=2C=C(C=C(F)C2C)C(=O)NC3CC3
Target	p38 MAPK

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

p38 MAPK

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