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Losmapimod hydrochloride

SKU: orb3172915

Description

Losmapimod hydrochloride (GW856553X) is an orally active, potent, and highly selective p38 alpha/beta MAPK inhibitor (IC50 = 0.8 nM). It greatly reduces the release of pro-inflammatory cytokines, including TNF-alpha and IL-6, by blocking inflammatory signaling cascades, showing remarkable efficacy in COPD and severe cardiovascular inflammation models.

Images & Validation

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Losmapimod hydrochloride

Key Properties

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CAS Number1246654-84-1
MW419.92
Purity99.98% (May vary between batches)
FormulaC22H27ClFN3O2
SMILESCl.O=C(NCC(C)(C)C)C1=CN=C(C=C1)C=2C=C(C=C(F)C2C)C(=O)NC3CC3
Targetp38 MAPK

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Quick Database Links

Gene Symbol
p38 MAPK

Protocol Information

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Available Sizes

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1 mg
$ 240.00
5 mg
$ 530.00
10 mg
$ 740.00
25 mg
$ 1,120.00
50 mg
$ 1,530.00
DispatchUsually dispatched within 5-10 working days
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