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Loxoribine

SKU: orb1308117

Description

Loxoribine is an orally active, selective TLR7 agonist and guanosine analog with immunostimulatory properties. It has demonstrated antiviral and antitumor activities in research, supporting its investigation in immunology and oncology for both in vitro and in vivo experimental applications.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number121288-39-9
MW336.30
Purity>98%
FormulaC13H17N5O6
SMILESNc1nc(=O)c2n(CC=C)c(=O)n(C3OC(CO)C(O)C3O)c2[nH]1
TargetTLR (Toll-like receptor)
SolubilitySoluble in DMSO up to 25 mg/ml

Bioactivity

In Vivo
In vivo, Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells.
In Vitro
Loxoribine selectively activates innate immune system cells through the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway, leading to the maturation of human monocyte-derived dendritic cells (DCs) and enhancing their Th-1- and Th-17-polarizing capability. Additionally, loxoribine (250 μM; 48 hours) promotes MoDCs maturation, evident from the increased expression of CD80, CD83, CD40, CD54, and CCR7.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

RWJ-21757

Similar Products

  • Loxoribine [orb1219584]

    >98% (HPLC)

    121288-39-9

    339.3

    C13H17N5O6

    2 mg, 10 mg, 25 mg, 50 mg, 100 mg, 5 mg, 200 mg, 500 mg, 1 g
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Key Properties

No computed properties available.

Protocol Information

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5 mg
$ 150.00
25 mg
$ 200.00
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