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Lufotrelvir

SKU: orb1685273

Description

Lufotrelvir (PF-07304814) is a 3CL protease inhibitor targeting SARS-CoV-2, designed for COVID-19 research. It exhibits broad-spectrum activity against related coronaviruses in vitro and has demonstrated antiviral efficacy in animal models, supporting its investigation for novel coronavirus infections.

Research Area

Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number2468015-78-1
MW552.51
Purity99.92%
FormulaC24H33N4O9P
SMILESO(C)C1=C2C(NC(C(N[C@H](C(N[C@@H](C[C@H]3C(=O)NCC3)C(COP(=O)(O)O)=O)=O)CC(C)C)=O)=C2)=CC=C1
TargetSARS-CoV
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.24 mM);H2O:30 mg/mL (54.3 mM);DMSO:100 mg/mL (180.99 mM)

Bioactivity

In Vivo
After intravenous administration to rats, dogs, and monkeys, Lufotrelvir exhibits favorable cardiovascular safety and pharmacokinetic parameters.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PF-07304814, SARS-CoV-2 3CL, SARSCoV
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

Lufotrelvir (orb1685273)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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2 mg
¥ 1,170.00
5 mg
¥ 2,080.00
10 mg
¥ 3,120.00
25 mg
¥ 5,720.00
50 mg
¥ 8,190.00
DispatchUsually dispatched within 6-8 weeks
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