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LY 344864

SKU: orb1703992

Description

LY 344864 is a selective 5-HT1F receptor agonist with a binding affinity (Ki) of 6 nM. It is a valuable research tool for investigating serotonergic systems in models of migraine and neuropathic pain, applicable in both in vitro and in vivo experimental studies.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number186544-26-3
MW351.42
Purity98.00%
FormulaC21H22FN3O
SMILESCl.CN(C)[C@@H]1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1
Target5-HT Receptor,Adrenergic Receptor
SolubilityDMSO:>10 mM;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.69 mM)

Bioactivity

Target IC50
5-HT1A receptor (human):0.530 μM (Ki)|5-HT7 receptor (human):4.851 μM (Ki)|α2 adrenergic receptor (rat):3.69 μM (Ki)|5-HT1F receptor (human):0.006 μM (Ki)|5-HT1E receptor (human):1.415 μM (Ki)|5-HT3A Receptor (human):3.935 mM (Ki)|5-HT1B receptor (human):0.549 μM (Ki)|5-HT1F:6 nM|5-HT1D receptor (human):0.575 μM (Ki)|5-HT2B receptor (human):1.695 μM (Ki)|5-HT2A receptor (human):3.499 μM (Ki)|α1 adrenoceptor (rat):5.06 μM (Ki)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Beta Receptor, BBB penetration, 5HTReceptor, 5-hydroxytryptamine Receptor, 5-HT1F, 5-HT Receptor, 5HT Receptor, Adrenergic Receptor, Inhibitor, inhibit, LY 344864, Parkinson's disease, LY344864, LY-344864, migraines, Serotonin Receptor

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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

LY 344864 (orb1703992)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
¥ 1,040.00
5 mg
¥ 1,300.00
1 ml x 10 mM (in DMSO)
¥ 1,430.00
10 mg
¥ 1,690.00
25 mg
¥ 2,730.00
50 mg
¥ 4,680.00
100 mg
¥ 7,800.00
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