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LY339434 HCl

SKU: orb1819272

Description

LY339434 HCl is a low-affinity agonist of the GluR5 kainate receptor. It induces rapid neuronal death primarily through NMDA receptor-mediated excitotoxicity, making it a research tool for studying excitatory neurotransmission and neurotoxicity in both in vitro and in vivo models.

Research Area

Neuroscience

Images & Validation

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LY339434 HCl

Key Properties

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MW349.81
Purity97.10% (May vary between batches)
FormulaC18H20ClNO4
SMILESOC([C@@H](N)C[C@H](C(O)=O)C/C=C/C1=CC2=C(C=CC=C2)C=C1)=O.Cl
TargetNMDAR,GluR
SolubilityDMSO:50 mg/mL (142.93 mM)

Bioactivity

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In Vitro
LY339434 HCl (1-1000 μM) caused a concentration-dependent decrease in cell viability (EC(50)=11.4+/-1.2 μM). Labeling with nucleic acid binding dyes revealed that LY339434 HCl induced a few apoptotic-like characteristics. These findings indicate that in cultured murine cortical neurons, LY339434 HCl acts predominantly through N-methyl-D-aspartate (NMDA) receptors rather than GluR5 to affect neuronal death that is rapid and involves predominantly necrosis rather than morphological apoptosis.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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mGluR5, LY339434 HCl, LY339434 HCl(219566-62-8 Free base), NMDA receptor
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
171360286 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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1 mg
$ 240.00
5 mg
$ 470.00
10 mg
$ 680.00
25 mg
$ 1,030.00
50 mg
$ 1,400.00
100 mg
$ 1,870.00
500 mg
$ 3,720.00
DispatchUsually dispatched within 3-5 working days
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