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LYN-1604 dihydrochloride

SKU: orb1298617

Description

LYN-1604 is a novel small molecule activator of ULK1. It induces cell death through mechanisms involving ATF3, RAD21, and caspase-3, concomitant with autophagy and apoptosis. This compound is a useful research tool for studying autophagy, cell death pathways, and oncology in both cellular and animal models.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number2310109-38-5
MW657.54
Purity99.80% (May vary between batches)
FormulaC33H45Cl4N3O2
SMILESCl.Cl.CC(C)CN(CC(C)C)CC(=O)N1CCN(CC(OCc2ccc3ccccc3c2)c2ccc(Cl)cc2Cl)CC1
TargetAutophagy|||Apoptosis
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.04 mM);DMSO:25 mg/mL (38.02 mM)

Customer Validated Data

The data below is submitted by researchers worldwide. We provide this transparency to help you decide if this product works for your specific application or species, even if we haven't tested it ourselves.
Success by Application
Reactivity Distribution

Latest Experiments

1 Results
Dilution
Sample
Summary
In vivo
Mouse
-
TM4 Sertoli cells
For LYN‑1604 (a ULK1 activator), cells...

Bioactivity

Target IC50
ULK1:18.94 nM (EC50)
In Vitro
LYN-1604, to be the best candidate for a ULK1 agonist. LYN-1604 induced cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. LYN-1604 has potential for good therapeutic effects on TNBC by targeting ULK1-modulated cell death in vivo

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

inhibit, LYN 1604, LYN 1604 Dihydrochloride, LYN 1604 dihydrochloride, LYN1604, LYN-1604, LYN-1604 2HCl, LYN1604 Dihydrochloride, LYN1604 dihydrochloride, LYN-1604 Dihydrochloride, LYN-1604 2HCl(2216753-86-3 free base), negative, Inhibitor, activator, 2216753-86-3, 2216753-86-3 free base, cancer, Apoptosis, anti-tumor, Autophagy, breast, TNBC, triple, Unc-51 like kinase, ULK, ULK1
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 mg
$ 70.00
5 mg
$ 120.00
1 ml x 10 mM (in DMSO)
$ 150.00
10 mg
$ 160.00
25 mg
$ 270.00
50 mg
$ 380.00
100 mg
$ 510.00
200 mg
$ 710.00
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