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Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD

SKU: orb1307901

Description

Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD

Research Area

Cardiovascular Research, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number1037589-69-7
MW528.55
Purity99.83% (May vary between batches)
FormulaC26H32N4O8
SMILESO=C(CCN1C(=O)C=CC1=O)NCCOCCOCCC(=O)Nc1ccc(CCC(=O)N2CCC2=O)cc1
TargetFGFR|||PROTAC Linker
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.57 mM);DMSO:125 mg/mL (236.5 mM)

Bioactivity

In Vivo
Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZDsuppresses oxidative-stress-induced inflammation in photoreceptors. Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZDdecreases the variability of retinal NRF2 levels and displays a trend (non-significant) towards increased NRF2 levels in Akita mice. Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZDdecreases retinal IL-1β mRNA expression in Akita mice. Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZDenhances cone-specific arrestin4 expression in Akita mice. Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZDrestores photoreceptor morphology in Akita mice. Administration of native FGF21 and Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD(3mg/kg or 10mg/kg; subcutaneously twice a week for two weeks) improves glucose tolerance and liver insulin sensitivity in Zucker rats. Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD(10 mg/kg; intraperitoneally injected) reduces retinal inflammation in diabetic mice .
In Vitro
PF-05231023 is a analog of long-acting fibroblast growth factor 21 .

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

inhibit, FGF21, FGF21-receptor, Mal amido PEG2 C2 amido Ph C2 CO AZD, MalamidoPEG2C2amidoPhC2COAZD, Mal-amido-PEG-2-C2-amido-Ph-C2-CO-AZD, Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD, Inhibitor, PF05231023, PF-05231023, PF 05231023, PROTACLinker, PROTAC Linker, PROTAC Linkers
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

5 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 100.00
10 mg
$ 120.00
25 mg
$ 180.00
50 mg
$ 270.00
100 mg
$ 400.00
DispatchUsually dispatched within 5-10 working days
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