Mal-N(Me)-C6-N(Me)-PNU-159682

SKU: orb3028351

Description

Mal-N(Me)-C6-N(Me)-PNU-159682 (Compound 27) is an active molecular conjugate used in antibody-drug conjugates (ADCs), consisting of the ADC linker Mal-N(Me)-C6-N(Me) and the potent cytotoxin PNU-159682. This compound selectively delivers its payload to cells expressing CD46 and releases PNU-159682 through cathepsin B cleavage of the linker, inducing DNA damage and apoptosis. Mal-N(Me)-C6-N(Me)-PNU-159682 has demonstrated sustained tumor regression in patient-derived xenograft (PDX) models of non-small cell lung cancer (NSCLC) and colorectal cancer (CRC).

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	2682939-57-5
MW	948.964
Formula	C₄₇H₅₆N₄O₁₇
SMILES	O([C@@H]1C2=C(C(O)=C3C(=C2O)C(=O)C=4C(C3=O)=CC=CC4OC)C[C@](C(COC(N(CCCCCCN(C(CN5C(=O)C=CC5=O)=O)C)C)=O)=O)(O)C1)[C@H]6C[C@@]7(N8[C@](O[C@@]7([C@H](C)O6)[H])([C@@H](OC)OCC8)[H])[H]
Target	Apoptosis,Drug-Linker Conjugates for ADC

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

Apoptosis,Drug-Linker Conjugates for ADC

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