Mardepodect hydrochloride

SKU: orb1687688

Description

Mardepodect HCl is a brain-penetrant, highly selective PDE10A inhibitor (IC50: 0.37 nM). It modulates gene expression, upregulating specific growth and signaling factors while downregulating cell cycle and apoptosis genes. This compound is a valuable research tool for investigating PDE10A's role in CNS disorders in both in vitro and in vivo models.

Research Area

Cell Biology, Metabolism Research

Images & Validation

−

Key Properties

−

CAS Number	2070014-78-5
MW	428.91
Purity	95.10% (May vary between batches)
Formula	C₂₅H₂₁ClN₄O
SMILES	Cl.Cn1cc(c(n1)-c1ccc(OCc2ccc3ccccc3n2)cc1)-c1ccncc1
Target	PDE,Apoptosis
Solubility	DMSO:20 mg/mL (46.63 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (5.83 mM)

Bioactivity

−

Target IC50	PDE10A:0.37 nM
In Vivo	Injecting Mardepodect hydrochloride (PF-2545920) into mice leads to a dose-dependent increase in striatal cyclic guanosine monophosphate (cGMP). Its median effective dose (ED50) is 1 mg/kg . Read more...

Storage & Handling

−

Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

PF-2545920 HCl, PF-02545920 HCl, Apoptosis, Mardepodect HCl, MP-10 HCl, PDE10A

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID

122412737 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols