Margetuximab Antibody

SKU: orb1980753

Description

Margetuximab (MGAH-22) is a second-generation, Fc-engineered monoclonal antibody targeting HER2, used in research for metastatic HER2-positive breast cancer. It is applied in both in vitro cell studies and in vivo tumor models to investigate therapeutic mechanisms and serves as a component in the development of targeted nanomedicines.

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	1350624-75-7
MW	145.86 kDa
Purity	95.00%
Target	HER,EGFR

Bioactivity

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Target IC50	HER2:39.33 ng/mL (EC50)
In Vivo	In a mouse model, weekly intraperitoneal injections of 2-4 mg/kg of Margetuximab (5-6 times) demonstrated significant tumor shrinkage on days 30-37. Margetuximab has been shown to increase tumor size in mice, and has been shown to increase tumor size in mice. In a study in cynomolgus monkeys, weekly intravenous injections of 15-150 mg/kg of Margetuximab (6 doses) were well tolerated and induced a mean reduction in NK cell counts by 51% and release of IL-6. A single dose of 50 mg/kg of intravenous Margetuximab demonstrated a favorable safety profile. Read more...
In Vitro	Margetuximab is a chimeric anti-HER2 monoclonal antibody with an optimized Fc structural domain and an EC50 value of 39.33 ng/mL.Margetuximab enhances the activity of effector cells against antibody-mediated cellular cytotoxicity (ADCC) mediated by antibody-dependent cells expressing the CD16A-158F variant. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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MGAH22, MGAH-22

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Gene Symbol

HER,EGFR

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