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Mc-Lys(PEG12)-Cap-Ala-Ala-PABC-exatecan

SKU: orb3173732

Description

Mc-Lys(PEG12)-Cap-Ala-Ala-PABC-exatecan (compound 12) is a drug-linker conjugate used in antibody-drug conjugates (ADCs). It comprises an ADC linker [Mc-Lys(PEG12)-Cap-Ala-Ala-PABC] and the DNA topoisomerase I inhibitor Exatecan. This compound is applicable for developing ADCs targeting HER2-positive breast cancer.

Images & Validation

Key Properties

CAS Number3067680-81-0
MW1731.97
FormulaC86H123FN10O26
SMILESN(C(OCC1=CC=C(NC([C@@H](NC([C@@H](NC(CCCCCNC([C@@H](NC(CCCCCN2C(=O)C=CC2=O)=O)CCCCNC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)=O)C)=O)C)=O)C=C1)=O)[C@@H]3C4=C5C(C=6N(C5)C(=O)C7=C(C6)[C@](CC)(O)C(=O)OC7)=NC=8C4=C(CC3)C(C)=C(F)C8
TargetDrug-Linker Conjugates for ADC,Topoisomerase

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information