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MC-VA-T-moiety(CH2-NH-CH3)-Exatecan

SKU: orb2565812

Description

MC-VA-T-moiety(CH2-NH-CH3)–Exatecan (compound 11-5) is a drug-linker conjugate designed for constructing antibody-drug conjugates (ADCs). This cleavable conjugate enables targeted delivery of the exatecan payload, a topoisomerase I inhibitor, and has demonstrated potent antitumor efficacy in preclinical in vitro and in vivo cancer models.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2857963-21-2
MW991.07
FormulaC52H59FN8O11
SMILESN(C(OCC1=C(CNC)C=C(NC([C@@H](NC([C@@H](NC(CCCCCN2C(=O)C=CC2=O)=O)[C@H](C)C)=O)C)=O)C=C1)=O)[C@@H]3C4=C5C(C=6N(C5)C(=O)C7=C(C6)[C@](CC)(O)C(=O)OC7)=NC=8C4=C(CC3)C(C)=C(F)C8

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

Protocol Information