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McN-A 343

SKU: orb1704379

Description

McN-A 343 is a selective M1 muscarinic receptor agonist that enhances ganglionic transmission. It has demonstrated efficacy in preclinical models, reducing inflammation and oxidative stress associated with ulcerative colitis, supporting research in gastroenterology and neuroimmunology.

Research Area

Neuroscience

Images & Validation

Key Properties

CAS Number55-45-8
MW317.21
Purity99.82%
FormulaC14H18Cl2N2O2
SMILES[Cl-].C[N+](C)(C)CC#CCOC(=O)Nc1cccc(Cl)c1
TargetAChR
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (10.4 mM);H2O:< 31.72 mg/mL;DMSO:90 mg/mL (283.72 mM)

Bioactivity

In Vivo
After the induction of 6% acetic acid colitis, treatment with McN-A 343 at a concentration of 1.5 mg/kg showed a significant reduction in intestinal damage as well as a decrease in wet weight, MPO activity, pro-inflammatory cytokine concentration, markers of oxidative stress and expression of inflammatory mediator.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

mAChR M1, McN A 343, McNA 343, McN-A 343, McN-A343, McN-A-343
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

McN-A 343 (orb1704379)

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25 mg
¥ 1,170.00
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¥ 1,560.00