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MCOPPB triHydrochloride

SKU: orb1306561

Description

MCOPPB triHydrochloride is a potent and selective agonist for the nociceptin/orphanin FQ peptide (NOP) receptor. This small molecule is a valuable research tool for investigating the NOP receptor's role in pain, anxiety, and depression through both in vitro binding assays and in vivo behavioral studies.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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MCOPPB triHydrochloride

Key Properties

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CAS Number1108147-88-1
MW518.01
Purity99.88% (May vary between batches)
FormulaC26H43Cl3N4
SMILESCl.Cl.Cl.CC1(CCCCCCC1)N1CCC(CC1)n1c(nc2ccccc12)[C@@H]1CCCNC1
TargetOpioid Receptor
SolubilityH2O:16.02 mg/mL (30.93 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.86 mM);DMSO:32.04 mg/mL (61.85 mM)

Bioactivity

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Target IC50
Nociceptin receptor:10.07 (pKi)
In Vivo
Only Parthenolide, the HDAC inhibitor with anti-inflammatory features, displayed a potent anti-apoptotic effect in Phb1 KO hepatocytes. Indeed, TSA and Parthenolide-treated hepatocytes showed increased levels of FXR, and reduced levels of CYP7A1, HDAC4, TNFα, TRAIL and Bax suggesting a less toxic effect of bile acids as a results of specific HDAC inhibition, resulting in the attenuation of the Phb1 KO hepatocytes apoptotic response. Importantly, Parthenolide exerts a protective effect from the liver injury after BDL in Phb1 KO mice. Indeed, Parthenolide treatment results in a reduction of the mortality rate of this mice after BDL associated with a lower apoptotic response as revealed by a reduction of necrotic areas, Tunel-staining, as well as decreased ALT (8431±957 vs.4225±210 U/L) and AST (4805±300 vs.2242±438 U/L) activities compared to control Phb1 KO mice.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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MCOPPB, MCOPPB 3HCl, MCOPPB Trihydrochloride, MCOPPB triHydrochloride, MCOPPB trihydrochlride, Inhibitor, OpioidReceptor, Opioid Receptor, inhibit

Similar Products

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  • MCOPPB trihydrochlride [orb1226977]

    >98% (HPLC)

    1108147-88-1

    518.01

    C26H43Cl3N4

    2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 200 mg, 500 mg, 1 g, 100 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
25208093 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

Select a size below

2 mg
$ 70.00
5 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 100.00
10 mg
$ 120.00
25 mg
$ 210.00
50 mg
$ 310.00
100 mg
$ 440.00
200 mg
$ 610.00
DispatchUsually dispatched within 3-5 working days
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