Mefuparib hydrochloride(CVL218)

SKU: orb654533

Description

Mefuparib(CVL218) hydrochloride is a potent, highly selective, competitive PARP1/2 inhibitor with IC50 of 3.2/1.9 nM, respectively.CVL218 was more potent than Remdesivir in blocking Coronavirus infection of cells and equally as potent as Remdesivir in blocking replication of virus once it has entered the cells.

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Key Properties

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CAS Number	1449746-00-2
MW	334.775
Purity	>98%
Formula	C₁₇H₁₆ClFN₂O₂
SMILES	O=C(C1=C(OC(C2=CC=C(CNC)C=C2)=C3)C3=CC(F)=C1)N.[H]Cl

Storage & Handling

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Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

117734810 ↗

Key Properties

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No computed properties available.

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María Ángeles Márquez-Moñino 1, Clara M Santiveri 2, Patricia de León 3, Sergio Camero 1, Ramón Campos-Olivas 2, M Ángeles Jiménez 1, Margarita Sáiz 3, Beatriz González 4, José Manuel Pérez-Cañadillas The ALS drug riluzole binds to the C-terminal domain of SARS-CoV-2 nucleocapsid protein and has antiviral activity Structure, (2024)

PubMed: 39541975