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Menaquinone-4

SKU: orb1220558

Description

Menaquinone-4 is a vitamin K compound used as a hemostatic agent and also as adjunctive therapy for the pain of osteoporosis.(In Vitro):Menaquinone-4 (MK-4, 0, 1, 5, 10 μM) increases the ALP activity in Caco-2 cells. Menaquinone-4 (1 μM) significantly increases intensities of hSI expression.(In Vivo):Menaquinone-4 (K2, 0.2 g/kg diet) in HF-K2 group produces epididymal fat in C57BL/6J mice, and also increases the bone density of mice.

Images & Validation

Key Properties

CAS Number863-61-6
MW444.65
Purity>98% (HPLC)
FormulaC31H40O2
SMILESCC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC1=C(C)C(=O)c2ccccc2C1=O
TargetOthers
SolubilityDMSO:20.83 mg/mL (46.85 mM)

Bioactivity

In Vivo
Menaquinone-4 (K2, 0.2 g/kg diet) in HF-K2 group produces epididymal fat in C57BL/6J mice, and also increases the bone density of mice.
In Vitro
Menaquinone-4 (MK-4, 0, 1, 5, 10 μM) increases the ALP activity in Caco-2 cells. Menaquinone-4 (1 μM) significantly increases intensities of hSI expression.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Vitamin K2 | Menaquinone K4

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Menaquinone-4 (orb1220558)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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