Methyclothiazide

SKU: orb1300639

Description

Methyclothiazide (Aquatensen) is a benzothiadiazide derivative used as an antihypertensive and diuretic agent. It is employed in research models of hypertension and edema, facilitating studies on renal sodium-chloride symporter (NCC) inhibition and fluid balance in both in vivo and in vitro experimental systems.

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	135-07-9
MW	360.24
Purity	99.13%
Formula	C₉H₁₁Cl₂N₃O₄S₂
SMILES	O=S1(=O)C=2C(NC(CCl)N1C)=CC(Cl)=C(S(N)(=O)=O)C2
Target	Carbonic Anhydrase
Solubility	H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:4 mg/mL (11.1 mM);DMSO:72 mg/mL (199.87 mM)

Bioactivity

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In Vivo

Methyclothiazide (0.1 g/L for the first 5 weeks and 0.2 g/L for the second 2 weeks, drinking water) attenuates development of hypertension in salt-sensitive (DS) rats, but does not affect blood pressure in salt-resistant (DR) ones. The methyclothiazide-treated DOCA-salt rats weigh less than controls or the nonsupplemented DOCA-salt rats at weeks 3 and 4. Methyclothiazide added to the drinking water of DOCA-salt rats attenuates the elevation of blood pressure.

In Vitro

Methyclothiazide (0.1 mM) reduces Ca2+ contractures with maximal inhibition of 90.4% in SHR aortic rings with endothelium. The inhibitory effect of Methyclothiazide (0.1 mM) on Ca2+ contracture is significantly but not totally abolished by the NO synthase inhibitor in SHR aortic rings with functional endothelium. Methyclothiazide (0.1 mM) induces endothelium-dependent inhibition of the vasoconstrictor responses to NE and AVP only in aortas from spontaneously hypertensive rats (SHR) rather than normotensive Wistar Kyoto rats (WKY), and the maximal vasoconstrictive effect of NE and AVP is decreased by 59% and 32.3%, respectively. Methyclothiazide (3.5 mM) inhibits renin release in rat kidney slices.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Duretic, Carbonate dehydratase, Carbonic Anhydrase, CarbonicAnhydrase, blood, Aquatensen, ?stroke,?heart attack,thiazide diuretics, edema, Enduron, Inhibitor, high, inhibit, Methyclothiazide, pressure

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Compound Identifiers

PubChem CID

4121 ↗

Key Properties

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No computed properties available.

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