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MFH290

SKU: orb1739549

Description

MFH290 is a selective covalent inhibitor targeting CDK12/13 via Cys-1039. It suppresses Pol II CTD Ser2 phosphorylation and DNA damage repair gene expression, synergizing with PARP inhibitors like olaparib in preclinical cancer models. This mechanism supports its research use in oncology, particularly for studying transcription-targeted therapies and synthetic lethality.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number2088715-91-5
MW525.69
FormulaC26H31N5O3S2
SMILESC(=O)(N1C[C@H](NC=2SC(SCC=3OC(C(C)(C)C)=CN3)=CN2)CCC1)C4=CC=C(NC(C=C)=O)C=C4
TargetOthers,CDK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

MFH290 (orb1739549)

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