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MI-773 TFA

SKU: orb3210026

Description

MI-773 TFA is an orally active selective inhibitor of the MDM2-p53 interaction, with a Ki value of 0.88 nM for MDM2. It effectively blocks the interaction between MDM2 and TP53, robustly activates p53, and induces apoptosis. MI-773 TFA causes tumor regression in adenoid cystic carcinoma xenograft models and exhibits anticancer effects in neuroblastoma. It is applicable in adenoid cystic carcinoma research.

Images & Validation

Key Properties

CAS Number1303609-37-1
MW676.53
FormulaC31H35Cl2F4N3O5
SMILESC(C(O)=O)(F)(F)F.C(C(C)(C)C)[C@@H]1[C@]2([C@H]([C@H](C(N[C@H]3CC[C@H](O)CC3)=O)N1)C4=C(F)C(Cl)=CC=C4)C=5C(NC2=O)=CC(Cl)=CC5
TargetMDM-2/p53,Apoptosis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information