Microtubulin-IN-1

SKU: orb3028635

Description

Microtubulin-IN-1 (Compound 8g) is an inhibitor of microtubulin, targeting the colchicine-binding site to disrupt tubulin integrity and induce upregulation of p53 protein expression. It exhibits antiproliferative activity across various cancer cell lines, including NCI-H460, BxPC-3, and HT-29, with IC50 values of 2.4, 1.6, and 2.07 nM, respectively. Additionally, Microtubulin-IN-1 induces cell cycle arrest at the G2/M phase and apoptosis in NCI-H460 cells.

Research Area

Cell Biology, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	3025180-14-4
MW	444.458
Formula	C₂₅H₂₁FN₄O₃
SMILES	C(\C=1N(C(C)C)C=CN1)=C\2/C(=O)N/C(=C\C3=CC(C(=O)C4=CC=C(F)C=C4)=CC=C3)/C(=O)N2
Target	MDM-2/p53,Microtubule Associated,Apoptosis

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

MDM-2/p53,Microtubule Associated,Apoptosis

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