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Milademetan

SKU: orb1709129

Description

Milademetan

Research Area

Cell Biology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number1398568-47-2
MW618.53
Purity100.00%
FormulaC30H34Cl2FN5O4
SMILESCC1(C)CCC2(CC1)N[C@H]([C@H](c1ccnc(Cl)c1F)[C@]21C(=O)Nc2cc(Cl)ccc12)C(=O)N[C@@H]1CC[C@H](OC1)C(N)=O
TargetMdm2,Apoptosis,E1/E2/E3 Enzyme,MDM-2/p53
SolubilityDMSO:55 mg/mL (88.92 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.62 mM)

Bioactivity

In Vivo
In mice xenografted with neuroblastoma cells possessing functional TP53, oral gavage administration of Milademetan (DS-3032) at a dose of 50 mg/kg delays tumor growth and improves overall survival.
In Vitro
Milademetan (DS-3032) selectively induces CDKNA1, BAX, and MDM2 expression and stabilizes TP53 in neuroblastoma cells with wild-type TP53. Treatment with Milademetan (DS-3032) enhances TP53 target gene expression, leading to G1 cell cycle arrest, senescence, and apoptosis. In neuroblastoma cells with wild-type TP53, independent of MYCN status, Milademetan (DS-3032, 0-2000 nM) treatment selectively inhibits viability, proliferation, and migration.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

MDM2, Mdm2, Milademetan, Apoptosis, DS 3032, DS3032, DS-3032, DS3032b, RAIN-32

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Key Properties

No computed properties available.

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Milademetan (orb1709129)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,690.00
5 mg
¥ 2,860.00
1 ml x 10 mM (in DMSO)
¥ 3,770.00
10 mg
¥ 4,290.00
25 mg
¥ 7,670.00
50 mg
¥ 12,220.00
100 mg
¥ 20,410.00
DispatchUsually dispatched within 3-5 working days
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