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Minesapride

SKU: orb1745243

Description

Minesapride is a novel partial agonist of the 5-HT4 receptor, developed as a gastrointestinal prokinetic candidate. Its potential for treating irritable bowel syndrome with constipation (IBS-C) is supported by in vitro receptor studies and in vivo models assessing gut motility.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1184662-54-1
MW454.95
Purity99.90%
FormulaC21H31ClN4O5
SMILESC(NC[C@H]1CN(CC2CCN(C(CO)=O)CC2)CCO1)(=O)C3=C(OC)C=C(N)C(Cl)=C3
Target5-HT Receptor
SolubilityDMSO:30 mg/mL (65.94 mM)

Bioactivity

In Vivo
Minesapride (1, 4, 12, or 40 mg; once daily; 4 weeks) improved in Minesapride 40 mg group abdominal symptoms score at week 4. In a phase 2 trial of patients with IBS-C in Japan, minesapride increased stool frequency (measured by CSBMs), reduced abdominal and overall IBS-C symptoms, and was well tolerated.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Minesapride, 5HT Receptor, 5-HT4, 5HTReceptor, (S)4amino5chloroN((4((1(2hydroxyacetyl)piperidin4yl)methyl)morpholin2yl)methyl)2methoxybenzamide

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    1184662-02-9

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    C21H31ClN4O5

    50 mg, 100 mg, 25 mg
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Key Properties

No computed properties available.

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Minesapride (orb1745243)

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Available Sizes

Select a size below

1 mg
¥ 2,080.00
5 mg
¥ 3,900.00
1 ml x 10 mM (in DMSO)
¥ 4,420.00
10 mg
¥ 5,590.00
25 mg
¥ 8,320.00
50 mg
¥ 11,570.00
100 mg
¥ 15,730.00
200 mg
¥ 20,930.00
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