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MK-0557

SKU: orb1296077

Description

MK-0557 is a potent, selective, and orally bioavailable neuropeptide Y5 receptor antagonist with a Ki of 1.6 nM. This compound is a valuable research tool for investigating the role of the Y5 receptor in appetite regulation and energy homeostasis, supporting both in vitro binding studies and in vivo pharmacological research.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number328232-95-7
MW406.41
Purity99.88% (May vary between batches)
FormulaC22H19FN4O3
SMILESFc1ccccc1-n1ccc(NC(=O)[C@H]2CC[C@]3(CC2)OC(=O)c2ccncc32)n1
TargetNeuropeptide Y Receptor
SolubilityDMSO:25 mg/mL (61.51 mM);10% DMSO+90% Corn Oil:2 mg/mL (4.92 mM)

Bioactivity

Target IC50
Y5 receptor:1.6 nM (Ki)
In Vivo
MK-0557 counteracts the NPY5R-selective agonist's influence on body-weight gain and hyperphagia in C57BL/6J mice, also markedly reducing body-weight gain in diet-induced obese (DIO) mice. A 40% reduction in body-weight gain is achieved by day 35 in lean mice shifted from regular chow to a medium high-fat diet (4.2 kcal/g), following treatment with MK-0557 at a dosage of 30 mg/kg PO QD.
In Vitro
MK-0557 has a Ki=1.3 nM at the human NPY5R, with similar affinities at rhesus, mouse, and rat NPY5R. MK-0557 has no significant binding to the human NPY1R, NPY2R, NPY4R, or mouse NPY6R at concentrations of 10 μM .

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

NPY receptor, inhibit, MK 0557, MK0557, MK-0557, NeuropeptideYReceptor, Neuropeptide Y Receptor, neuropeptide Y (NPY) Y5 receptor, neuropeptide Y (NPY) receptor, Inhibitor, Y5 receptor

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 90.00
2 mg
$ 110.00
5 mg
$ 150.00
1 ml x 10 mM (in DMSO)
$ 170.00
10 mg
$ 210.00
25 mg
$ 340.00
50 mg
$ 530.00
100 mg
$ 730.00
200 mg
$ 1,000.00
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