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ML-335

SKU: orb1704356

Description

ML-335 is a μ-δ isomer-targeted agonist and a μOR-δOR-biased ligand, functioning as a MOR/DOR heterodimer scaffold. It exhibits anti-nociceptive and pain inhibitory activities, making it a valuable tool for studying biased agonism and novel analgesic mechanisms in both in vitro and in vivo research.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1069498-96-9
MW408.53
Purity98.58%
FormulaC25H32N2O3
SMILESCCOC(=O)C1(CCc2ccccc2)CCN(Cc2ccc(NC(C)=O)cc2)CC1
TargetOpioid Receptor
SolubilityDMSO:9 mg/mL (22.03 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.45 mM)

Bioactivity

Target IC50
μ opioid receptor:0.125 µM(EC50)
In Vivo
CYM51010 (ML-335) (subcutaneous injection; SNL rats) inhibited mechanical hypersensitivity in a dose-related manner (EC50: 1.09 mg/kg) and also reversed heat hyperalgesia and attenuated ongoing pain (2 mg/kg, subcutaneously).

Storage & Handling

StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Opioid Receptor, OpioidReceptor, ML 335, ML335, ML-335, μ-opioid receptor, δ-opioid receptor

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Key Properties

No computed properties available.

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Protocol Information

ML-335 (orb1704356)

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% DMSO +
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% Tween 80 +
%

Available Sizes

Select a size below

1 ml x 10 mM (in DMSO)
¥ 910.00
5 mg
¥ 1,040.00
10 mg
¥ 1,430.00
25 mg
¥ 2,210.00
50 mg
¥ 3,120.00
100 mg
¥ 4,290.00
200 mg
¥ 5,720.00
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