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ML188

SKU: orb1298991

Description

ML188 is a selective, noncovalent inhibitor of the SARS-CoV 3CL protease (IC50 = 1.5 µM). This moderate molecular weight compound demonstrates good inhibitory activity in enzymatic and antiviral cell-based assays, making it a useful chemical probe for coronavirus research.

Research Area

Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number1417700-13-0
MW433.54
Purity99.69% (May vary between batches)
FormulaC26H31N3O3
SMILESCC(C)(C)NC(=O)[C@H](N(C(=O)c1ccco1)c1ccc(cc1)C(C)(C)C)c1cccnc1
TargetVirus Protease,SARS-CoV
SolubilityDMSO: 4.34 mg/mL (10.01 mM), sonication is recommended.

Bioactivity

Target IC50
3CLpro (SARS CoV):1.5 μM
In Vitro
Probe 16-(R) (ML188) is a modest molecular weight SARS-CoV 3CLpro inhibitor with demonstrated antiviral activity and a non-covalent mechanism of action.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

antiviral, infection, Inhibitor, inhibit, non-covalent, ML 188, ML188, ML-188, SARS-CoV, SARS coronavirus, SARSCoV, replication, probe, Virus Protease, VirusProtease

Similar Products

  • ML188 enantiomer [orb2814023]

    1417700-12-9

    433.54

    C26H31N3O3

    50 mg, 10 mg
Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

ML188 (orb1298991)

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% DMSO +
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% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,170.00
5 mg
¥ 2,860.00
1 ml x 10 mM (in DMSO)
¥ 3,120.00
10 mg
¥ 3,900.00
25 mg
¥ 6,240.00
50 mg
¥ 8,970.00
100 mg
¥ 12,610.00
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