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ML311

SKU: orb1221202

Description

ML311 is a selective inhibitor of the Mcl-1/Bim interaction.

Images & Validation

Key Properties

CAS Number315698-17-0
MW415.45
Purity>98% (HPLC)
FormulaC23H24F3N3O
SMILESCCN1CCN(CC1)C(c1ccc(cc1)C(F)(F)F)c1ccc2cccnc2c1O
TargetBcl-2
SolubilityDMSO: 20 mg/mL;Water: Insoluble;Ethanol: 20 mg/mL

Bioactivity

In Vitro
ML311 potently halts viability of several types of Mcl-1 primed cells, including MCL-1-1780 (EC50 = 0.31 μM), DHL-6 (EC50 = 3.3 μM), and NCI-H929 (EC50 = 1.6 μM), with generally high maximal effect (> 80%). ML311 also displays activity in a leukemia-derived cell line particularly reliant upon Bcl-2 function (Bcl2-1863, EC50 = 1.1 μM). ML311 has strong growth inhibitory effects in many cell lines, with GI50<900 nM for nine cell types (RPMI-8226, SR, NCI-H322M, NCI-H60, HCC-2998, KM12, SF-295, U251, PC-3 cell lines), and <2 μM for 14 additional types.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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    99.75% (May vary between batches)

    315698-17-0

    415.45

    C23H24F3N3O

    50 mg, 100 mg, 5 mg, 10 mg, 1 mg, 25 mg, 1 ml x 10 mM (in DMSO)
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Protocol Information

ML311 (orb1221202)

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Available Sizes

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200 mg
500 mg
2 mg
¥ 1,300.00
5 mg
¥ 1,820.00
10 mg
¥ 2,600.00
25 mg
¥ 4,550.00
50 mg
¥ 7,930.00
100 mg
¥ 11,310.00