Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

ML382

SKU: orb1298851

Description

ML382 is a selective positive allosteric modulator of the MrgX1 receptor, exhibiting an EC50 of 190 nM. This small molecule is a valuable research tool for investigating MrgX1 function in vitro and exploring its potential role in pain and itch pathways in vivo.

Research Area

Neuroscience

Images & Validation

Key Properties

CAS Number1646499-97-9
MW360.5
Purity>98%
FormulaC18H20N2O4S
SMILESCCOc1ccccc1NC(=O)c1ccccc1NS(=O)(=O)C1CC1
TargetGPCR
SolubilitySoluble in DMSO (at least 25 mg/ml) or in Ethanol (up to 5 mg/ml, with warming).

Bioactivity

Target IC50
MrgX1:190 nM(EC50)
In Vivo
ML382 enhances the ability of BAM8-22 to inhibit high-voltage-activated Ca2+ channels and attenuate spinal nociceptive transmission, both BAM8-22 and ML382 effectively attenuated evoked, persistent, and spontaneous pain without causing obvious side effects. Notably, ML382 by itself attenuated both evoked pain hypersensitivity and spontaneous pain in MrgprX1 mice after nerve injury without acquiring coadministration of an exogenous agonist

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

VU0485891; 2-(Cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide

Similar Products

  • ML382 [orb1220019]

    >98% (HPLC)

    1646499-97-9

    360.42

    C??H??NO?

    5 mg, 50 mg, 100 mg, 10 mg, 25 mg, 200 mg, 500 mg, 1 g
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

10 mg
$ 220.00
50 mg
$ 480.00
DispatchUsually dispatched within 5-10 working days
Bulk Enquiry