MLL2 (N) Antibody, Rabbit Polyclonal

SKU: orb66850

Description

Rabbit polyclonal to MLL2.MLL2 is a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). H3K4merepresents a specific tag for epigenetic transcriptional activation. MLL2 plays a central role in betaglobinlocus transcription regulation by being recruited by NFE2. MLLS acts as a coactivator forestrogen receptor by being recruited by ESR1, thereby activating transcription. MLL2 is also requiredduring the transcriptionally active period of oocyte growth for the establishment and/or maintenance ofbulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption ofmeiosis, oocyte survival and normal zygotic genome activation.

Research Area

Epigenetics

Images & Validation

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Tested Applications	WB
Dilution range	WB:1:1000-1:5000
Reactivity	Human, Mouse

Key Properties

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Host	Rabbit
Clonality	Polyclonal
Immunogen	N-terminal region of human MLL2
Molecular Weight	593
Purity	Affinity purification
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	0.01% NaN3
Disclaimer	For research use only

Alternative Names

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anti-MLL2 antibody,anti-Histonelysine Nmethyltransferase MLL2 antibody,anti-ALL1related protein antibody,anti-ALR antibody,anti-KMT2B antibody,anti-Lysine Nmethyltransferase 2B antibody,anti-Myeloid antibody,anti-lymphoid or mixedlineage leukemia protein 2 antibody

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Western blot analysis of total cell extracts from mouse brain(Lane1) and human K562(Lane2) using MLL2 antibody

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UniProt

O14686

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No UniProt data available

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Protocol Information

Western Blot (IB, immunoblot)

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