MLN-4760

SKU: orb1308021

Description

MLN-4760 is a potent and selective inhibitor of human angiotensin-converting enzyme 2 (ACE2; IC50=0.44 nM). It exhibits >5000-fold selectivity over related enzymes like ACE and carboxypeptidase A. This compound is a valuable research tool for studying ACE2 function in vitro and in SARS-CoV-2 viral entry mechanisms.

Research Area

Metabolism Research

Images & Validation

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Item 1 of 1

Key Properties

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CAS Number	305335-31-3
MW	428.31
Purity	99.05% (May vary between batches)
Formula	C₁₉H₂₃Cl₂N₃O₄
SMILES	CC(C)C[C@H](N[C@@H](Cc1cncn1Cc1cc(Cl)cc(Cl)c1)C(O)=O)C(O)=O
Target	RAAS
Solubility	H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.67 mM)

Bioactivity

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Target IC50	ACE2 (human):0.44 nM (IC50)\|Carboxypeptidase A (bovine):27 μM (IC50)
In Vivo	MLN-4760 (100 μM, intracerebroventricular infusion for five days) significantly exacerbates neurological function at 4 hours and 3 days post-stroke, without a notable increase in infarct volume.
In Vitro	MLN-4760 displays pIC50 at rhACE2 of 8.5±0.1 and at rhACE of 4.4±0.2. MLN-4760 also shows pIC50 at rhACE2 of 4.7±0.1, 6.9±0.1, and an ACE of 4.4±0.1, 6.2±0.1 in murine heart and mononuclear cells (MNCs), respectively. MLN-4760 potently quenches the cleavage of the 7-Mca-YVADAPK(Dnp) in rhACE2.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Human ACE2, Inhibitor, MLN4760, MLN-4760, MLN 4760, inhibit, ACE, Angiotensin-converting Enzyme (ACE), Bovine carboxypeptidase A

Quality Guarantee

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Compound Identifiers

PubChem CID

448281 ↗

Key Properties

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No computed properties available.

Protocol Information

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CAS Number:	305335-29-9
MW:	428.31
Formula:	C₁₉H₂₃Cl₂N₃O₄

MLN-4760

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Bioactivity

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Alternative Names

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