Cart summary

You have no items in your shopping cart.

MM3122

SKU: orb1301173

Description

MM3122 is a potent and selective TMPRSS2 inhibitor with an IC50 of 0.34 nM. It blocks viral entry of SARS-CoV-2 and MERS-CoV into host cells in vitro, making it a valuable research tool for studying coronavirus pathogenesis and host-directed antiviral strategies.

Research Area

Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number2574390-27-3
MW665.76
Purity>99.99% (May vary between batches)
FormulaC31H39N9O6S
SMILESC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC(CNC(C)=O)=O)CCC(N)=O)=O)=O)CCCNC(=N)N)(=O)C2=NC=3C(S2)=CC=CC3
TargetSARS-CoV
SolubilityDMSO:90 mg/mL (135.18 mM)

Bioactivity

In Vivo
MM3122, administered intraperitoneally (i.p.) at doses ranging from 0-100 mg/kg daily for 7 days, showed no adverse effects, including no weight loss or changes in harvested organs (liver, spleen, and kidney), when compared to control subjects. Additionally, a single i.p. dose of MM3122 at 16.7 mg/kg was found to have a plasma half-life of 8.6 hours and a lung half-life of 7.5 hours in NSG mice.
In Vitro
MM3122 (0-1 μM) exhibits inhibitory activity against HGFA, matriptase, hepsin, and thrombin with IC50 values of 32 nM, 0.31 nM, 0.19 nM, and over 20 nM, respectively. Additionally, MM3122 (0.1-100 μM) inhibits SARS-CoV-2 calu-3, MERS VSV pseudotype calu-3, and VSV-SARS CoV-2 chimera calu-3 with EC50 values of 74 nM, 0.87 nM, and 0.43 nM, respectively .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

GTPL 11533, GTPL11533, GTPL-11533, MM3122, MM-3122, MM 3122, Ac-GQFR-kbt, SARS-CoV, SARSCoV
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

MM3122 (orb1301173)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,560.00
5 mg
¥ 2,860.00
10 mg
¥ 4,160.00
25 mg
¥ 6,630.00
50 mg
¥ 9,360.00
100 mg
¥ 12,740.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry