Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

Mogroside V

SKU: orb1304779

Description

Mogroside V is a natural sweetener with demonstrated AMPK-activating, antioxidant, and anti-inflammatory properties in vitro. Research indicates its potential in models of acute lung injury (ALI), ear edema, and pancreatic cancer, highlighting applications in metabolic, inflammatory, and oncology studies.

Research Area

Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Signal Transduction

Images & Validation

−
Mogroside V

Key Properties

−
CAS Number88901-36-4
MW1287.43
Purity≥98% (May vary between batches)
FormulaC60H102O29
SMILESC[C@H](CC[C@@H](O[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(C)(C)O)[C@H]1CC[C@@]2(C)[C@@H]3CC=C4[C@@H](CC[C@H](O[C@@H]5O[C@H](CO[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)[C@@H](O)[C@H](O)[C@H]5O)C4(C)C)[C@]3(C)[C@H](O)C[C@]12C
TargetROS,Reactive Oxygen Species,AMPK
SolubilityH2O:100 mg/mL (77.67 mM);Ethanol:Soluble;DMSO:50 mg/mL (38.84 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (1.55 mM)

Bioactivity

−
In Vivo
Female BALB/c mice were treated with Mogroside V (2.5, 5 and 10 mg/kg) for 1 h prior to intranasal injection of LPS (10 μg in 50 μl). After 12 h, airway inflammation in the ALI model was determined by the wet/dry weight (W/D) ratio, myeloperoxidase (MPO) activity of lung tissue, leukocyte recruitment and cytokine levels in the bronchoalveolar lavage fluid (BALF). Additionally, lung tissue was examined by histology and western blotting to investigate the changes in pathology and the signalling in the presence and absence of Mogroside V. Mogroside V at 5 and 10 mg/kg inhibited airway inflammation induced by LPS as measured by the decrease in the histological changes (44 and 67.3% reduction in lung injury score, respectively), a 28.9 and 55.3% reduction in lung MPO activity, and inflammatory cell counts, interleukin-1β (IL-1β, 382 and 280 pg/ml, respectively), IL-6 (378 and 232 pg/ml, respectively) and tumor necrosis factor-α (TNF-α, 12.5 and 7.8 ng/ml, respectively) levels in the BALF. Additionally, Mogroside V treatment reduced the activation of cyclooxygenase 2 (COX-2), inducible NO synthase (iNOS), and the nuclear factor (NF)-κB.
Read more...

Storage & Handling

−
Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

−
AMPK, Mogroside V, inhibit, Inhibitor

Similar Products

−
  • 11-oxo-mogroside V

    11-oxo-mogroside V [orb1303751]

    98.00% (May vary between batches)

    126105-11-1

    1285.42

    C60H100O29

    1 mg, 25 mg, 10 mg, 50 mg, 5 mg, 1 ml x 10 mM (in DMSO), 100 mg
  • Isomogroside V

    Isomogroside V [orb1297332]

    97.07% (May vary between batches)

    1126032-65-2

    1287.43

    C60H102O29

    10 mg, 50 mg, 100 mg, 25 mg, 1 mg, 5 mg
  • 11-epi-mogroside V

    11-epi-mogroside V [orb1691179]

    99.05% (May vary between batches)

    2146088-12-0

    1287.45

    C60H102O29

    5 mg, 50 mg, 10 mg, 25 mg, 1 mg
  • 7β-Methoxy-Mogroside V

    7β-Methoxy-Mogroside V [orb2893158]

    50 mg, 10 mg
  • 7-oxo-Mogroside V

    7-oxo-Mogroside V [orb3179435]

    99.99% (May vary between batches)

    942612-72-8

    1301.42

    C60H100O30

    1 mg, 5 mg, 50 mg, 25 mg, 10 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
24721270 ↗

Key Properties

−
No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

Find More Protocols

Mogroside V (orb1304779)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Login to review

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

5 mg
¥ 1,430.00
10 mg
¥ 1,820.00
1 ml x 10 mM (in DMSO)
¥ 2,340.00
25 mg
¥ 2,730.00
50 mg
¥ 4,160.00
100 mg
¥ 5,330.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry
Need technical support? Find your Distributor Return and Tax Policy

Email

[email protected]

UK Office

+44 (0)1223 859353

US Office

+1 (415) 906-5211

CN Office

+86 (27)-87663101

Distributors

biorbyt.com/distributor