Moxifloxacin hydrochloride

SKU: orb1310715

Description

Moxifloxacin hydrochloride is a fourth-generation fluoroquinolone antibiotic with enhanced activity against Gram-positive and atypical pathogens. It is widely used in research for in vitro susceptibility testing and in vivo infection model studies. Its use has been associated with transient ALT elevations and rare cases of clinically apparent liver injury.

Research Area

Infectious Disease & Virology, Molecular Biology

Images & Validation

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Key Properties

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CAS Number	186826-86-8
MW	437.89
Purity	>99.99% (May vary between batches)
Formula	C₂₁H₂₅ClFN₃O₄
SMILES	O(C)C1=C2N(C=C(C(O)=O)C(=O)C2=CC(F)=C1N3C[C@]4([C@@](C3)(NCCC4)[H])[H])C5CC5.Cl
Target	Antibiotic,Topoisomerase,Antibacterial
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.54 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:88 mg/mL (200.96 mM);H2O:15 mg/mL (34.26 mM)

Bioactivity

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In Vivo

Moxifloxacin exhibits a broad spectrum of antibacterial activity both in vitro and clinically against various pathogens, including Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, H. parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Chlamydophila pneumoniae, and Mycoplasma pneumoniae. It functions by stabilizing the DNA-drug-enzyme complex, thereby inhibiting ATP-dependent topoisomerase II (DNA gyrase) and topoisomerase IV, critical enzymes for bacterial DNA replication, transcription, repair, and recombination.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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community-acquired, chronic, bronchitis, Bacterial, BAY 128039, BAY 12-8039, BAY128039, BAY-128039, BAY12-8039 HCl, antimicrobial, Antibiotic, acute, 8-methoxyquinolone, Inhibitor, exacerbations, Moxifloxacin, Moxifloxacin HCl, Moxifloxacin Hydrochloride, Moxifloxacin hydrochloride, inhibit, Topo IV, Topo II, pneumonia, sinusitis

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Compound Identifiers

PubChem CID

101526 ↗

Key Properties

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No computed properties available.

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