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MPP+ iodide

SKU: orb1298313

Description

MPP+ iodide is a neurotoxic metabolite used to model Parkinson's disease, selectively destroying dopaminergic neurons via DAT externalization while internalizing SERT in serotonergic neurons. It is widely applied in neuroscience research to study neurodegenerative mechanisms, including autophagic cell death in vitro models like SH-SY5Y cells.

Research Area

Cell Biology, Metabolism Research

Images & Validation

Key Properties

CAS Number36913-39-0
MW297.13
Purity99.96% (May vary between batches)
FormulaC12H12IN
SMILESI.c1ccc(cc1)-c1ccncc1
TargetMitochondrial Metabolism|||Autophagy
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.46 mM);H2O:100 mg/mL (336.55 mM);DMSO:135 mg/mL (454.35 mM)

Bioactivity

In Vivo
METHODS: To test for acute toxicity to embryonic or neonatal mice, MPP+ iodide (8.6-34.2 mg/kg) was injected intraperitoneally into pregnant or neonatal mice. RESULTS: Neurotoxicity induced by a single injection of MPP+ iodide was transient and recoverable in embryonic and neonatal mice. In contrast, no significant changes in MAO-A and MAO-B expression levels were observed in MPP+ iodide-treated mice.
In Vitro
METHODS: Human neuroblastoma cells SH-SY5Y were treated with MPP+ iodide (1-4 mM) for 12-48 h, and cell viability was detected using CCK-8 Assay.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, inhibit, MPP+, MPP+ iodide, MPP+ Iodide, neurotoxic, neurons, Mitochondrial Metabolism, MitochondrialMetabolism, Autophagy, complex, chain, dopaminergic, respiratory

Similar Products

  • MPP+ iodide [orb1218096]

    >98% (HPLC)

    36913-39-0

    297.13

    C12H12IN

    10 mg, 50 mg, 1 g, 25 mg, 100 mg, 200 mg, 500 mg
Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

5 mg
$ 80.00
10 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 90.00
25 mg
$ 110.00
50 mg
$ 140.00
100 mg
$ 210.00
200 mg
$ 290.00
500 mg
$ 440.00
1 g
$ 690.00
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