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MRE-269

SKU: orb1223120

Description

MRE-269, also known as ACT-333679, is a long-acting and highly selective prostacyclin receptor agonist. MRE-269, the active form or metabolite of Selexipag (NS-304), is much more selective for the IP receptor than are the prostacyclin analogs beraprost and iloprost, which also have high affinity for the EP(3) receptor.

Images & Validation

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MRE-269

Key Properties

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CAS Number475085-57-5
MW419.52
Purity>98% (HPLC)
FormulaC25H29N3O3
SMILESCC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(=O)C5(C)C)C)C)C2C1C)C)C(=O)O
TargetHIV-1 protease
SolubilityDMSO : ≥ 50 mg/mL. 119.18 mM; H2O : < 0.1 mg/mL

Bioactivity

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In Vivo
The vasorelaxant effects of MRE-269 on rat small intralobar pulmonary artery (SIPA) and EPA are the same, while the other IP receptor agonists induce less vasodilation in SIPA than in EPA. MRE-269 produces substantial relaxation of rat small pulmonary artery, although its effects are only significant at high concentrations of above 10 μM (pEC50, 4.98±0.22). By contrast, in rat small pulmonary veins, MRE-269 only produces minimal relaxation over the whole concentration range, with only significant relaxation occurring at the two highest doses of MRE-269 of 10 and 100 μM.
In Vitro
MRE-269 induces endothelium-independent vasodilation of rat extralobar pulmonary artery (EPA). MRE-269 or other IP receptor agonists including epoprostenol, iloprost, treprostinil and beraprost increase cAMP levels in hPASMC. MRE-269 induces concentration-dependent vasodilation in LPA(+), LPA(-), and SPA(-).

Storage & Handling

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StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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MRE-269 | MRE269 | MRE 269 | ACT-333679

Similar Products

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  • MRE-269 [orb1303362]

    98.25% (May vary between batches)

    475085-57-5

    419.52

    C25H29N3O3

    25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO), 5 mg, 10 mg
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Quick Database Links

Gene Symbol
HIV-1 protease

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5 mg
$ 90.00
10 mg
$ 140.00
25 mg
$ 220.00
50 mg
$ 290.00
100 mg
$ 480.00
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