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MSU-42011

SKU: orb1744034

Description

MSU-42011 is a potent, orally bioavailable RXR agonist that suppresses iNOS, SREBP, and p-ERK protein expression. It exhibits immunomodulatory and antitumor efficacy in preclinical models, including in vivo studies of KRAS-driven lung cancer, highlighting its utility in oncology and immunology research.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Images & Validation

Key Properties

CAS Number2456434-36-7
MW382.54
Purity99.60%
FormulaC24H34N2O2
SMILESN(CC(C)C)(C1=CC(C(C)(C)C)=CC(C(C)(C)C)=C1)C2=CC=C(C(O)=O)C=N2
TargetNO Synthase,Retinoid Receptor,Ras,Kras,ERK,NOS,Lipid
SolubilityDMSO:45 mg/mL (117.63 mM)

Bioactivity

Target IC50
iNOS:158 nM
In Vivo
MSU-42011 (25 mg/kg; oral; for 12 weeks) significantly reduced the number, size, and overall tumor burden of tumors in the A/J mouse lung cancer model. Compared with the control group, there were fewer cells with active proliferation and showed a significant decrease in p-ERK . MSU-42011 (25 mg/kg; oral; single dose) is most effective in reducing the number, size, and overall tumor burden of the A/J mouse lung cancer model in combination with C/P. Reduced macrophages in the lungs and increased activation markers of CD8+T cells . MSU42011 (100 mg/kg; PO; single dose) reduces tumor burden in a mouse lung tumor model .
In Vitro
MSU-42011 (300 nM; 8 h) showed a low induction effect on SREBP in HepG2 cells. MSU-42011 (0-5000 nM; 24 h) can activate RXR in HepG2 cells.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

6((3,5ditertbutylphenyl)(isobutyl)amino)nicotinicacid, Inos, MSU 42011, MSU42011, MSU-42011, NOSynthase, NO Synthase, Retinoid Receptor, RetinoidReceptor, SREBP, RXR, PERK
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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MSU-42011 (orb1744034)

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% DMSO +
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% Tween 80 +
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Available Sizes

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5 mg
¥ 1,170.00
10 mg
¥ 1,430.00
25 mg
¥ 2,210.00
50 mg
¥ 3,120.00
100 mg
¥ 4,680.00
200 mg
¥ 6,240.00
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