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MXC-017

SKU: orb3135273

Description

MXC-017 is an apoptosis inducer capable of crossing the blood-brain barrier, specifically targeting glioma stem cells (GSCs). It effectively prevents the formation of radiation-induced GSCs while promoting G0/G1 cell cycle arrest and apoptosis. With minimal off-target effects, MXC-017 exhibits no significant cytotoxicity even at concentrations up to 10 µM. Additionally, it significantly extends the median survival in patient-derived orthotopic xenograft (PDOX) glioblastoma (GBM) mouse models when used in conjunction with radiation therapy.

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Key Properties

CAS Number3037024-97-5
MW397.49
FormulaC21H23N3O3S
SMILESO=C(NCC1=CC=C(C=C1)S(=O)(=O)N2CCCCC2)N3C=CC=4C=CC=CC43
TargetApoptosis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information

MXC-017 (orb3135273)

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