MYCMI-6

SKU: orb1309378

Description

MYCMI-6 is a selective small molecule inhibitor that disrupts the MYC:MAX protein interaction. It demonstrates potent anti-tumor activity in MYC-driven models, significantly reducing proliferation and inducing apoptosis in vivo with a favorable toxicity profile. This inhibitor is a valuable research tool for studying MYC biology and oncology in both cellular and animal experiments.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	681282-09-7
MW	373.41
Purity	99.23% (May vary between batches)
Formula	C₂₀H₁₉N₇O
SMILES	CCOc1ccc2nc3cc(ccc3c(N)c2c1)\N=N\c1ccc(N)nc1N
Target	c-Myc,Apoptosis
Solubility	DMSO:2.3 mg/mL (6.16 mM)

Bioactivity

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In Vivo

MYCMI-6 induces massive apoptosis and reduces tumor cell proliferation, tumor microvasculature density and MYC:MAX interaction in a MYC-dependent xenograft tumor model.

In Vitro

MYCMI-6 in a cell-based protein interaction screen for small inhibitory molecules. MYCMI-6 exhibits strong selective inhibition of MYC:MAX interaction in cells and in vitro at single-digit micromolar concentrations, as validated by split Gaussia luciferase, in situ proximity ligation, microscale thermophoresis and surface plasmon resonance (SPR) assays. Further, MYCMI-6 blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with a KD of 1.6 0.5 μM as demonstrated by SPR. MYCMI-6 inhibits tumor cell growth in a MYC-dependent manner with IC50 concentrations as low as 0.5 μM, while sparing normal cells. The response to MYCMI-6 correlates with MYC expression based on data from 60 human tumor cell lines and is abrogated by MYC depletion. Further, it inhibits MYC:MAX interaction, reduces proliferation and induces massive apoptosis in tumor tissue from a MYC-driven xenograft tumor model without severe side effects.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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athymic, Apoptosis, cytotoxic, cMyc, c-Myc, c-Myc-MAX, cells, nude, mice, neuroblastoma, Myc, MYCMI 6, MYCMI6, MYCMI-6, MYC-driven, inhibit, NSC 354961, NSC354961, NSC-354961, lymphoma, MCF7, Inhibitor, tumor

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Compound Identifiers

PubChem CID

434695 ↗

Key Properties

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No computed properties available.

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MYCMI-6

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

MYCMI-6 (orb1309378)

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