Myelin Basic Protein (MBP) (68-82), guinea pig

SKU: orb1296755

Description

Images & Validation

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Key Properties

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CAS Number	98474-59-0
MW	1736.79
Purity	100.00%
Formula	C₇₁H₁₁₃N₂₃O₂₈
SMILES	C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(N)=O)C(O)=O)=O)CCC(O)=O)=O)CC(O)=O)=O)CCC(N)=O)=O)CO)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CO)=O)CCCCN)=O)CCC(N)=O)(=O)[C@H]1N(C([C@@H](NC([C@@H](NC(CNC([C@H](CC2=CC=C(O)C=C2)N)=O)=O)CO)=O)CC(C)C)=O)CCC1
Target	Others
Solubility	DMSO:10 mM

Bioactivity

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In Vivo

This study investigates the impact of preemptive bee venom acupuncture (BVA) treatment, starting from the day of myelin basic protein (MBP) (68-82) immunization, on the onset and progression of experimental autoimmune encephalomyelitis (EAE) and associated weight loss. After immunization, rats in the MBP group began showing early signs of EAE, such as partial loss of tail tone, within 5-9 days, progressing to more severe neurological symptoms, including various degrees of limb paralysis, between 10-16 days. In contrast, rats treated with BVA exhibited milder neurological impairments, with a dose-dependent reduction in symptom severity and delayed onset of symptoms (BVA 0.8 mg/kg, 6.4±0.6 days) observed 11-15 days post-immunization. Additionally, the maximum clinical score was significantly lower in the BVA-treated groups (BVA 0.25 mg/kg, 3.7±0.2; BVA 0.8 mg/kg, 2.8±0.3) compared to the untreated MBP group. Moreover, while the MBP group's mean body weight decreased, the MBP + BVA group's mean body weight significantly increased compared to the MBP-only group, highlighting a potential protective effect of BVA against EAE-induced weight loss and symptom severity.

Storage & Handling

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Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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MBP (68-82), guinea pig, MBP , guinea pig, inhibit, Myelin Basic Protein (MBP) (68 82), guinea pig, Myelin Basic Protein (MBP) (6882), guinea pig, Myelin Basic Protein (MBP) (68-82), guinea pig, Myelin Basic Protein (MBP) , guinea pig, Inhibitor

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Compound Identifiers

PubChem CID

71464368 ↗

Key Properties

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No computed properties available.

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