N-acetylcysteine amide

SKU: orb1301727

Description

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	38520-57-9
MW	162.21
Purity	99.98%
Formula	C₅H₁₀N₂O₂S
SMILES	CC(=O)N[C@@H](CS)C(N)=O
Target	ROS,Reactive Oxygen Species
Solubility	DMSO:245 mg/mL (1510.39 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (30.82 mM);H2O:100 mg/mL (616.48 mM)

Bioactivity

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In Vivo	METHODS: To assay antitumor activity in vivo LAT1-IN-1 (200 mg/kg) was administered intravenously to BALB/c nude mice bearing KYSE150 tumors once daily for 14 days. Results: Daily treatment with LAT1-IN-1 for 14 consecutive days significantly delayed tumor growth. Read more...
In Vitro	METHODS: Human esophageal cancer cells KYSE30 and KYSE150 were treated with LAT1-IN-1 (1-100 mM) for 3 days, and cell viability was measured by MTT assay. Results: LAT1-IN-1 treatment inhibited cell proliferation in a dose-dependent manner. METHODS: HTR8 SVneo, JEG-3 and JAR cells were treated with LAT1-IN-1 (0.1-4 µM) for 24 h, an the expression levels of target proteins were detected by Western Blot. Results: LAT1 protein was significantly reduced after 24 h LAT1-IN-1 treatment, and LAT1-IN-1 could directly regulat the expression of LAT1. Read more...
Cell Research	To determine effectiveness of NACA and NAC in protection of H9c2 cells from DOX-induced toxicity, cells were treated with NACA or NAC at 0.75 mM for 2 h followed by exposure to freshly prepared cell culture medium with DOX in presence or absence of NACA or NAC at designated concentration the concentration of DOX were 0.25 μM, 0.75 μM, 2 μM, 5 μM, 20 μM, and 100 μM the exposure durations were 24 h, 48 h, or 48 h. Cells incubated with NACA or NAC alone were used a the contro. Read more...
Animal Research	Rats were andomly divided into three groups ( = -8 animals/group): N-acetylcysteine amide loaded pump (18.5 mg/kg/hr) and a Single 150 mg/kg bolus intraperitoneal (IP) injection of NACA given (30 min post-injury) N-acetylcysteine amide (18.5 mg/kg/hr) loaded pump and a Single 150 mg/kg bolus injection of N-acetylcysteine amide given IP (30 min post-injury) Vehicle loaded pump and Single Vehicle bolus injection given IP (30 min post-injury). Following andom distribution of All animals into one on the three previous groups, experimenters were blinded to treatment group the osmotic mini pumps were assembled and implanted immediately after injury and remained in the animals for 7 days. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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inhibit, N acetylcysteine amide, Nacetylcysteine amide, N-Acetylcysteine amide, N-acetylcysteine Amide, Inhibitor, ReactiveOxygenSpecies, Reactive Oxygen Species, ROS

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Compound Identifiers

PubChem CID

10176265 ↗

Key Properties

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No computed properties available.

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