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nAChR agonist 1

SKU: orb1309361

Description

DUN71755 is a brain-penetrant and orally active positive allosteric modulator of the α7 nicotinic acetylcholine receptor. This small molecule tool compound is used in research to investigate α7 nAChR function in models of cognitive disorders and neuroinflammation, supporting both in vitro and in vivo experimental studies.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1394371-75-5
MW419.94
Purity97.17% (May vary between batches)
FormulaC20H18ClNO3S2
SMILESCCC(=O)c1sc(c(C)c1-c1ccc(cc1)S(N)(=O)=O)-c1ccc(Cl)cc1
TargetAChR
SolubilityDMSO:120 mg/mL (285.76 mM)

Bioactivity

In Vivo
nAChR agonist 1(compound 28) is a novel PAM of α7 nicotinic acetylcholine receptor (α7 nAChR). Compound 28 showed good in vitro potency, with pharmacokinetic profile across species with excellent brain penetration and residence time. Compound 28 robustly reversed the cognitive deficits in episodic/working memory in both time-delay and scopolamine-induced amnesia paradigms in the novel object and social recognition tasks, at very low dose levels.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Nicotinic acetylcholine receptors, neuroblastoma, nAChR agonist 1, nAChR, nAChR agonist1, nAChR agonist-1, oral, Inhibitor, inhibit, cognitive, cells, deficits, DUN71755, DUN-71755, DUN 71755, disease, Alzheimer's, brain-permeable, α7 nAChR

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 100.00
5 mg
$ 150.00
1 ml x 10 mM (in DMSO)
$ 170.00
10 mg
$ 210.00
25 mg
$ 310.00
50 mg
$ 400.00
100 mg
$ 530.00
DispatchUsually dispatched within 3-5 working days
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