NBDHEX

SKU: orb1309351

Description

NBDHEX is a potent and selective inhibitor of the glutathione S-transferase P1-1 (GSTP1-1) enzyme. This small molecule is a valuable research tool for investigating GSTP1-1 function in cancer cell resistance and for probing detoxification pathways in both cellular and biochemical assays.

Research Area

Cell Biology, Metabolism Research

Images & Validation

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Key Properties

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CAS Number	787634-60-0
MW	297.33
Purity	97.38% (May vary between batches)
Formula	C₁₂H₁₅N₃O₄S
SMILES	N(=O)(=O)C=1C=2C(C(SCCCCCCO)=CC1)=NON2
Target	Autophagy,Glutathione Peroxidase,GST,Apoptosis
Solubility	DMSO:125 mg/mL (420.41 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.45 mM)

Bioactivity

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In Vivo

NBDHEX, In female mice, treatment results in a statistically significant tumour inhibition (approximately 70%) .

In Vitro

NBDHEX not only is cytotoxic toward the parental small cell lung cancer H69 cell line (LC(50) of 2.3 +/- 0.6 micromol/L) but also overcomes the multidrug resistance of its variant, H69AR, which overexpresses the ATP-binding cassette transporter multidrug resistance-associated protein 1 (MRP1; LC(50) of 4.5 +/- 0.9 micromol/L). Drug efflux experiments, done in the presence of a specific inhibitor of MRP1, confirmed that NBDHEX is not a substrate for this export pump .

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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p38MAPK, NBDHEX, JNK, inhibit, Glutathione Peroxidase, GlutathionePeroxidase, GSSG, GSTP1-1, extrusion, Inhibitor, c-Jun, catalytic, cytotoxic, Apoptosis, anticancer, Autophagy

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Compound Identifiers

PubChem CID

9817686 ↗

Key Properties

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No computed properties available.

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NBDHEX (orb1309351)

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NBDHEX

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

NBDHEX (orb1309351)

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