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NCGC00685960

SKU: orb3173084

Description

NCGC00685960 is a potent inhibitor of nicotinamide N-methyltransferase (NNMT) with an IC50 of less than 10 nM. This compound exhibits strong anti-tumor activity, enhances H3K27 trimethylation in ovarian cancer cells, and suppresses α-SMA expression in NNMT-expressing ovarian fibroblasts. It also reduces 1-MNA levels in cancer-associated fibroblasts (CAFs), reverses low SAM and H3K27 methylation, and significantly diminishes collagen contractility. NCGC00685960 is valuable for cancer research.

Images & Validation

Key Properties

CAS Number3091000-99-3
MW458
FormulaC24H32ClN5O2
SMILESO=C1N(C2=C3C(=CC=C2)C=CC(=O)N3)N=C(N1)[C@@H]4CN(CCC5CCCCC5)CCC4.Cl
TargetOthers

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information